Cancer Panels Gene List

Below are the lists of genes included in each specific cancer panel. These products available from commercial providers while clinically and biologically relevant based on the guidelines of College of American Pathologists (CAP), NCCN, Clinical trials, The Cancer Genome Atlas (TCGA) and Ingenuity knowledge base but nevertheless available for “Research Use” only and not intended for the diagnosis, prevention, or treatment of a disease.

illumina’s Cancer Panels

illumina provides 4 different Cancer panels with varying number of genes, targets, target size and capture chemistries. To help facilitate making the decision, below is a side by side comparison of 4 illumina’s cancer panels.


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Qiagen’s Human Cancer Predisposition Panel

The Human Cancer Predisposition GeneRead DNAseq Targeted Panel is a multiplexed PCR-based assay for targeted enrichment of the coding (exonic) regions of the 143 genes commonly mutated in following 88 inherited oncogenic diseases.


  • Bloom Syndrome: BLM
  • Carney Complex: PRKAR1A
  • Costello Syndrome: HRAS
  • Cowden Syndrome: AKT1, PIK3CA, PTEN
  • Hereditary Desmoid Disease: APC
  • Li-Fraumeni Syndrome: CHEK2 (RAD53), TP53
  • LIG4 Syndrome: LIG4
  • Lynch Syndrome: EPCAM, MLH1, MSH2, MSH6, PMS2
  • Mismatch Repair Cancer Syndrome: MLH1, MSH2, MSH6, PMS2
  • Mosaic Variegated Aneuploidy: BUB1B
  • Seckel Syndrome 1: ATR
  • von Hippel-Lindau Syndrome: VHL

Bone Cancers:

  • Familial Osteosarcoma: TP53
  • Hereditary Bone Dysplasia with Malignant Fibrous Histiocytoma: MTAP
  • Multiple Exostoses: EXT1, EXT2
  • Rothmund-Thompson Syndrome: RECQL4

Colorectal Cancers:

  • Hereditary Adenomatous Polyposis: APC, MUTYH
  • Hereditary Colorectal Cancer: GALNT12, MLH3
  • Oligodontia-Colorectal Cancer Syndrome: AXIN2
  • POLD1 & POLE Associated Colorectal Adenomas: POLD1, POLE

Breast/Ovarian Cancers:

  • Hereditary Breast-Ovarian Cancer: BARD1, BRCA1, BRCA2, CHEK2 (RAD53), RAD51B (RAD51L1), RAD51C, RAD51D (RAD51L3)

Endocrine Cancers:

  • Hereditary Adrenal Pheochromocytoma: MAX, TMEM127, VHL
  • Hereditary Primary Pigmented Nodular Adrenocortical Disease: PDE11A, PRKAR1A
  • Hereditary Adrenocortical Cancer: TP53
  • Hereditary Adrenal Hyperplasia: CYP21A2
  • Hereditary Isolated Pituitary Adenoma: AIP
  • Hereditary Thyroid Cancer: NDUFA13, NTRK1, RET
  • Hyperparathyroidism-Jaw Tumor Syndrome: CDC73
  • Multiple Endocrine Neoplasia: CDKN1B (p27KIP1), MEN1
  • Pallister-Hall Syndrome: GLI3

GI Tract Cancers:

  • Bannayan-Riley-Ruvalcaba Syndrome: PTEN
  • Hereditary Barrett Esophagus/Esophageal Adenocarcinoma: ASCC1, MSR1
  • Hereditary Gastric Carcinoma: CDH1
  • Hereditary GIST: KIT (CD117), PDGFRA, SDHC
  • Howel-Evans syndrome: RHBDF2
  • Juvenile Polyposis Syndrome: BMPR1A (ALK3), SMAD4
  • Peutz-Jeghers Syndrome: STK11 (LKB1)

Hematopoietic Cancers:

  • Ataxia Telangetasia: ATM
  • Ataxia Telangetasia-like Disorder: MRE11A
  • Chediak-Higashi Syndrome: LYST
  • Familial Monocytic Leukemia: GATA2
  • Hereditary Acute Myeloid Leukemia: CEBPA, RUNX1 (AML1)
  • Hereditary Hodgkin Lymphoma: KLHDC8B
  • Nijmegen Breakage Syndrome: NBN (NBS1)
  • Nijmegen Breakage-like Syndrome: RAD50
  • Schwachman-Diamond Syndrome: SBDS
  • TERT Mutation-Associated Haematological Disorders: TERT
  • Wiskott-Aldrich Syndrome: WAS

Head & Neck Cancers:

  • Dyskeratosis Congenita: DKC1, RTEL1, TERT, TINF2
  • Hereditary Cylindromatosis: CYLD
  • Tuberous Sclerosis: TSC1, TSC2

Kidney Cancers:

  • Birt-Hogg-Dube Syndrome: FLCN
  • Denys-Drash Syndrome: WT1
  • Hereditary Leiomyomatosis & Renal Cell Cancer: FH
  • Hereditary Melanoma & Renal Cancer: MET, MITF
  • Hereditary Wilms’ Tumor: POU6F2, WT1
  • Perlman Syndrome: DIS3L2

Liver Cancers:

  • Hemochromatosis: HFE
  • Porphyria Cutanea Tarda: UROD
  • Tyrosinemia: FAH

Nervous System Cancers:

  • Carney-Stratakis Syndrome: PRKAR1A, SDHAF2, SDHB, SDHD
  • Hereditary Medulloblastoma: SUFU
  • Hereditary Neuroblastoma: ALK, KIF1B, PHOX2B
  • Hereditary Paragangliomas: SDHA
  • Neurofibromatosis: NF1, NF2
  • Retinoblastoma: RB1
  • Rhabdoid Predisposition Syndrome: SMARCA4, SMARCB1
  • Schwannomatosis: SMARCB1
  • Simpson-Golabi-Behmel Syndrome: GPC3

Skin Cancers:

  • Basal Cell Nevus Syndrome: PTCH1, PTCH2
  • Birt-Hogg-Dube Syndrome: FLCN
  • Familial Multiple Glomus Tumors: GLMN
  • Familial Multiple Trichoepithelioma: CYLD
  • Familial Uveal Melanoma: BAP1
  • Ferguson-Smith Syndrome: TGFBR1 (ALK5)
  • Hereditary Epidermodysplasia Verruciformis: TMC6, TMC8
  • Hereditary Leiomyomatosis & Renal Cell Cancer: FH
  • Hereditary Malignant Melanoma: CDK4, CDKN2A (p16INK4), MC1R, MITF, XRCC3
  • Muir-Torre Syndrome: MSH2
  • Palmoplantar Keratoderma & Squamous Cell Carcinoma: RSPO1
  • Xeroderma Pigmentosum: DDB2, ERCC2 (XPD), ERCC3 (XPB), ERCC4, ERCC5, ERCC6, POLH, XPA, XPC

Soft Tissue Cancers:

  • Hereditary Infantile Hemangioma: ANTXR1, KDR (VEGFR3)
  • Juvenile Hyaline Fibromatosis: ANTXR2
  • Opitz Trigonocephaly Syndrome: CD96
  • Proteus Syndrome: PTEN
  • SC Phocomelia Syndrome: ESCO2
  • Werner Syndrome: WRN

Other Cancers:

  • Familial Pancreatic Cancer: BRCA2, PALB2, PALLD
  • Hereditary Pleuropulmonary Blastoma: DICER1
  • Hereditary Prostate Cancer: BRCA2, EHBP1, EPHB2, MSMB, MSR1, RNASEL

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Qiagen’s Disease Specific Cancer Panels

The Human Cancer GeneRead DNAseq Targeted Panels are multiplexed PCR-based assays for targeted enrichment of the coding (exonic) regions of the listed genes commonly mutated in specific diseases.

For additional Gene Panel Lists or to customize a panel

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